تأثیر یرقان انسدادی حاد بر روی پارامترهای اسپرم موش های صحرائی بالغ

Introduction & Objective: Obstructive cholestasis is associated with overproduction of endogenous opioids , nitric oxide and cytokins in the blood streams. These consequences may affect sex hormones since proper fertility will be resulted from physiological balance of sex hormones, we investigated the relationship between obstructive cholestasis and gonadotropins and sperm parameters in adult male rats. Materials & Methods: To study this, we used three groups of animals: control (No-surgery), Sham (surgical control), and cholestatic (surgical ligation of the bile duct). After 3 weeks all animals were killed by ether, and serum concentrations of FSH and LH were determined by radioimmunoassay, sperm parameters were evaluated by light microscop. Results: The findings of this study showed that LH and FSH levels decreased significantly in cholestatic compared to control and sham groups (p0.05). Conclusion: These findings indicated that obstructive cholestasis lead to decrease in the levels of serum gonadotropins, but it has no significant effect on sperm parameters. We speculated that spermatogenesis, and sperm parameters were not dependent on gonadotropin hormones but other factors may involved.